Preheat the oven to 400°F (200°C). Line a baking sheet with parchment paper for easy cleanup.
In a shallow bowl, combine the panko breadcrumbs, flour, garlic powder, onion powder, paprika, salt, and black pepper.
Dip each chicken breast in the beaten eggs, allowing excess to drip off, then coat it thoroughly in the breadcrumb mixture.
Place the coated chicken breasts on the prepared baking sheet and lightly brush each with olive oil.
Bake for 25-30 minutes, flipping halfway through, until the chicken is golden brown and cooked through (internal temperature should reach 165°F/74°C).
While the chicken bakes, prepare the hot honey sauce: in a small saucepan, combine honey, hot sauce, red pepper flakes, apple cider vinegar, and a pinch of salt. Cook over low heat, stirring until heated through and slightly thickened, about 5 minutes.
Once the chicken is baked, remove it from the oven and drizzle the hot honey sauce over the top.
Serve warm with a side of your choice and enjoy the sweet and spicy flavors!